Rapamycin pre-treatment protects against apoptosis
نویسندگان
چکیده
منابع مشابه
Rapamycin pre-treatment protects against apoptosis.
Macroautophagy (generally referred to as autophagy) mediates the bulk degradation of cytoplasmic contents, including proteins and organelles, in lysosomes. Rapamycin, a lipophilic, macrolide antibiotic, induces autophagy by inactivating the protein mammalian target of rapamycin (mTOR). We previously showed that rapamycin protects against mutant huntingtin-induced neurodegeneration in cell, fly ...
متن کاملPre-treatment with rapamycin protects hematopoiesis against radiation injury
Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...
متن کاملRapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...
متن کاملRapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
OBJECTIVES Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. MATERIALS AND METHODS Seventy-two adult male Wistar rats we...
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The amyloidb peptide (A b ) can mediate cell attachment by binding to b 1 integrins through an arg-his-asp sequence. We show here that the a 5 b 1 integrin, a fibronectin receptor, is an efficient binder of A b , and mediates cell attachment to nonfibrillar A b . Cells engineered to express a 5 b 1 internalized and degraded more added A b 1-40 than did a 5 b 1-negative control cells. Deposition...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2006
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddl036